PKC nu Proteins, Antibodies, cDNA Clones Research Reagents

PRKD3 (Protein Kinase D3) is a protein coding gene located on human chromosome 2p22.2. PRKD3 is also known as EPK2, PKD3, PRKCN, PKC-NU, and nPKC-NU. The human PRKD3 gene encodes a 100471 Da protein containing 890 amino acids. The PRKD3 protein is ubiquitously expressed in lymph node, testis and other tissues. Among its related pathways are Sweet Taste Signaling and Integrin Pathway. PRKD3 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. PRKD1 is an important paralog of PRKD3 gene. PRKD3 is associated with some diseases, including Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease and Cystic Kidney Disease.

PKC nu Protein (1)

    PKC nu Antibody (1)

      PKC nu cDNA Clone (30)

      NM_005813.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_029239.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      PKC nu Lysate (1)

        PKC nu の背景知識

        Serine/threonine-protein kinase D3, also known as Protein kinase C nu type, Protein kinase EPK2, PRKD3, EPK2 and PRKCN, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD3 / PRKCN contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. They also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. PRKD3 / PRKCN converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. It is involved in resistance to oxidative stress. PRKD3 / PRKCN is activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains 1 and 2 bind both DAG and phorbol ester with high affinity and mediate translocation to the cell membrane. Autophosphorylation of Ser-735 and phosphorylation of Ser-731 by PKC relieves auto-inhibition by the PH domain. PRKD3 / PRKCN can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. PRKD3 / PRKCN can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phospholipase C gamma and the involvement of other PKC family members.

        PKC nu の参考文献

        • Schultz SJ, et al.,1994, Cell Growth Differ. 4 (10): 821-30.
        • Hayashi A, et al., 1999, Biochim Biophys Acta 1450 (1): 99-106.
        • Mayne M, et al., 2000, J. Immunol. 164 (12): 6538-42.
        • Ali A, et al., 2002, Chem. Rev. 101 (8): 2527-40.

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