PITPNB Antibodies, cDNA Clones Research Reagents

PITPNB (Phosphatidylinositol Transfer Protein Beta, also known as VIB1B; PtdInsTP; PI-TP-beta), located on 22q12.1, is a Protein Coding gene. This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. The gene produces a 31540 Da protein composed of 271 amino acids. Phosphatidylinositol transfer protein is a member of a diverse set of cytosolic phospholipid transfer proteins that are distinguished by their ability to transfer phospholipids between membranes in vitro. Disease such as Cleft Soft Palate is associated with PITPNB.

PITPNB Antibody (1)

    PITPNB cDNA Clone (30)

    BC018704

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_053742.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    PITPNB qPCR Primer (2)

    ほかの人気製品

    PITPNB の背景知識

    PITPNB (Phosphatidylinositol Transfer Protein Beta) is a Protein Coding gene. The PITPNB gene, located on 22q12.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog. This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. Diseases associated with PITPNB include Cleft Soft Palate. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. 208 organisms have orthologs with the human gene PITPNB.

    PITPNB の参考文献

    • Morgan CP, et al. (2006) Differential expression of a c-terminal splice variant of phosphatidylinositol transfer protein beta lacking the constitutive-phosphorylated ser262 that localizes to the golgi compartment. Biochem J 398 (3): 411-421.
    • Kim WK, et al. (2008) Comparative proteomic analysis of peripheral blood mononuclear cells from atopic dermatitis patients and healthy donors. BMB Rep 41 (8): 597-603.
    • Carvou N, et al. (2010) Phosphatidylinositol- and phosphatidylcholine-transfer activity of pitpbeta is essential for copi-mediated retrograde transport from the golgi to the endoplasmic reticulum. J Cell Sci 123 (Pt 8): 1262-1273.

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