PIR Antibodies, cDNA Clones Research Reagents

PIR (Pirin), located on Xp22.2, is a Protein Coding gene. This gene encodes a member of the cupin superfamily. The gene produces a 32113 Da protein composed of 290 amino acids. The Pirin, a product of the PIR gene, is an iron-binding protein acting as a transcriptional coregulator implicated in the regulation of the NF-κB-related transcription via interaction with RelA (p65), as well as BCL3 and NF-κB1 (p50) proteins. Diseases such as Paranoid Personality Disorder and Exhibitionism are associated with PIR.

PIR Antibody (1)

    PIR cDNA Clone (30)

    NM_001018109.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_027153.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    PIR の背景知識

    Pirin (PIR) protein belongs to the superfamily of cupin and is highly conserved between eukaryotic and prokaryotic organisms. The Pirin, a product of the PIR gene, is an iron-binding protein acting as a transcriptional coregulator implicated in the regulation of the NF-κB-related transcription via interaction with RelA (p65), as well as BCL3 and NF-κB1 (p50) proteins. It has been reported that PIR is upregulated in various tumors and involved in tumorigenesis. Alterations in Pirin expression were observed in various tumors and under oxidative stress conditions. PIR is a potential druggable target for the therapy of cancers with a high expression level of PIR. PIR might be a promising diagnostic marker for HSPC and CRPC. Furthermore, CRPC treatment strategies targeting PIR may be possible in the future. Identification of antitumor miRNAs, including miRNA passenger strands, may contribute to the development of new diagnostic markers and therapeutic strategies for CRPC.

    PIR の参考文献

    • Suleman M, et al. (2019) Pir promotes tumorigenesis of breast cancer by upregulating cell cycle activator e2f1. Cell Cycle 18 (21): 2914-2927.
    • Brzóska K, et al. (2014) Basal pir expression in hela cells is driven by nrf2 via evolutionary conserved antioxidant response element. Mol Cell Biochem 389 (1-2): 99-111.
    • Arai T, et al. (2019) Pirin: A potential novel therapeutic target for castration-resistant prostate cancer regulated by mir-455-5p. Mol Oncol 13 (2): 322-337.

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