PIPOX Antibodies, cDNA Clones Research Reagents

PIPOX (Pipecolic Acid And Sarcosine Oxidase, also known as LPIPOX), located on 17q11.2, is a Protein Coding gene. The gene produces a 44066 Da protein composed of 390 amino acids. PIPOX encodes pipecolic acid oxidase, an enzyme that degrades L-pipecolic acid and sarcosine in peroxisomes. PIPOX contains an N-terminal ADP-beta-alpha-beta binding fold and a covalent FAD-binding site, and a C-terminal type 1 peroxisomal targeting sequence (PTS1). Diseases such as Inflammatory Bowel Disease 15 and Zellweger Syndrome are associated with PIPOX.

PIPOX Antibody (1)

    PIPOX cDNA Clone (30)

    BC008960

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_008952.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    PIPOX qPCR Primer (1)

    PIPOX の背景知識

    PIPOX (Pipecolic Acid And Sarcosine Oxidase, also known as L-pipecolate oxidase) is a Protein Coding gene. The PIPOX gene, located on 17q11.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, S.pombe, N.crassa, A.thaliana, rice, and frog. This enzyme oxidizes L-pipecolic acid with the concomitant production of H2O2 in the peroxisome of the normal human liver. Pipecolate, an intermediate of the lysine catabolic pathway, is oxidized to Δ1 -piperideine-6-carboxylate (P6C) by the PIPOX. Diseases associated with PIPOX include Inflammatory Bowel Disease 15 and Zellweger Syndrome. Among its related pathways are Lysine degradation and Viral mRNA Translation. 215 organisms have orthologs with the human gene PIPOX.

    PIPOX の参考文献

    • Rao VV, et al. (1990) L-pipecolic acid metabolism in human liver: Detection of l-pipecolate oxidase and identification of its reaction product. Biochim Biophys Acta 1038 (3): 295-299.
    • Natarajan SK, et al. (2017) Evidence for pipecolate oxidase in mediating protection against hydrogen peroxide stress. J Cell Biochem 118 (7): 1678-1688.
    • Dodt G, et al. (2000) The human l-pipecolic acid oxidase is similar to bacterial monomeric sarcosine oxidases rather than d-amino acid oxidases. Cell Biochem Biophys 32 Spring 313-316.

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