PIP/GCDFP 15 Antibodies, cDNA Clones Research Reagents

PIP (Prolactin Induced Protein, also known as GPIP4; GCDFP15; GCDFP-15), located on 7q34, is a Protein Coding gene. The gene produces a 16572 Da protein composed of 146 amino acids. PIP is a small secreted glycoprotein carrying several N-linked carbohydrate chains and is present in seminal plasma, saliva, lacrimal fluid, tears, sweat gland secretion. PIP can have immunomodulatory functions and plays an important role in cell-mediated adoptive immunity. Diseases such as Breast Cyst and Microglandular Adenosis are associated with PIP.

PIP/GCDFP 15 Antibody (2)

    PIP/GCDFP 15 cDNA Clone (13)

    BC010950

    クローニングベクター cDNA 製品

    In lentiviral vector

    PIP/GCDFP 15 qPCR Primer (1)

    PIP/GCDFP 15 の背景知識

    Prolactin-induced protein (PIP) is a small secreted glycoprotein carrying several N-linked carbohydrate chains. The expression of PIP is generally restricted to cells with apocrine properties. It was found in the apocrine glands of the axilla, vulva, eyelid, ear canal, and seminal vesicle. Being a secretory protein, PIP is present in seminal plasma, saliva, lacrimal fluid, tears, sweat gland secretion. The available data suggest that PIP can have immunomodulatory functions and plays an important role in cell-mediated adoptive immunity. PIP binds to bacteria from several genera, which suggests that this glycoprotein may participate also in innate immunity and protection of hosts against microbial infections. Increased levels of PIP were found in several types of human cancer (prostate, sweat, and salivary gland cancers). It is especially common in breast cancer, however, data on the expression of PIP in normal and cancerous breast cancer tissues are to some degree conflicting.

    PIP/GCDFP 15 の参考文献

    • Urbaniak A, et al. (2018) Prolactin-induced protein (pip)-characterization and role in breast cancer progression. Am J Cancer Res 8 (11): 2150-2164.
    • Gangadharan A, et al. (2018) Prolactin induced protein (pip) is a potential biomarker for early stage and malignant breast cancer. Breast 39 101-109.

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