Pin1 Proteins, Antibodies, cDNA Clones Research Reagents

PIN1 (Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1) is a protein coding gene located on human chromosome 19p13.2. PIN1 is also known as DOD and UBL5. The human PIN1 gene encodes a 18243 Da protein containing 163 amino acids. The PIN1 protein is ubiquitously expressed in brain, testis and other tissues. Among its related pathways are Regulation of TP53 Activity through Acetylation and Regulation of TP53 Activity. PIN1 is related to peptidyl-prolyl cis-trans isomerase activity and mitogen-activated protein kinase kinase binding. PIN4 is an important paralog of PIN1 gene. PIN1 is associated with some diseases, including Lower Gum Cancer and Gastric Liposarcoma.

Pin1 Protein (2)

    Pin1 Antibody (1)

      Pin1 cDNA Clone (44)

      NM_006221.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_023371.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      Pin1 qPCR Primer (1)

      Pin1 の背景知識

      Peptidyl-prolyl cis-trans isomerase Pin1, also known as Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Rotamase Pin1 and PIN1, peptidyl-prolyl cis/trans isomerase (PPIase), is a nucleus protein. PIN1 is a peptidyl-prolyl isomerase that can alter the conformation of phosphoproteins and so affect protein function and/or stability. PIN1 regulates a number of proteins important for cell-cycle progression and is presumed to operate as a molecular timer of this important process. PIN1 is an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. PIN1 displays a preference for an acidic residue N-terminal to the isomerized proline bond. Alterations in the level of PIN1 can influence hyperproliferative diseases such as cancer. PIN1 has been implicated in multiple aspects of cell cycle regulation. It has been suggested that PIN1 function is required for both normal mitotic progression and reentry into the cell cycle from quiescence. PIN1 is also a target of several oncogenic pathways and is overexpressed in human breast cancer. Its overexpression can lead to upregulation of cyclin-D1 and transformation of breast epithelial cells in collaboration with the oncogenic pathways. PIN1 plays a pivotal role in breast development and may be a promising new anticancer target. Pin1 activity regulates the outcome of proline-directed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival. Recent data also implicate Pin1 as playing an important role in immune responses, at least in part by increasing the stability of cytokine mRNAs by influencing the protein complexes to which they bind.

      Pin1 の参考文献

      • Liou YC, et al. (2003) Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature. 424(6948): 556-61.
      • Ryo A, et al. (2001) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol. 3(9): 793-801.
      • Geldner N, et al. (2001) Auxin transport inhibitors block PIN1 cycling and vesicle trafficking. Nature. 413(6854): 425-8.

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