PIK3CD cDNA Clones Research Reagents

PIK3CD (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta) is a protein coding gene located on human chromosome 1p36.22. PIK3CD is also known as APDS, PI3K, IMD14, p110D, and P110DELTA. The human PIK3CD gene encodes a 119479 Da protein containing 1044 amino acids. The PIK3CD protein is broadly expressed in lymph node, bone marrow and other tissues. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and GDNF-Family Ligands and Receptor Interactions. PIK3CD is related to transferase activity, transferring phosphorus-containing groups and kinase activity. PIK3CB is an important paralog of PIK3CD gene. PIK3CD is associated with some diseases, including Immunodeficiency 14 and Roifman-Chitayat Syndrome.

PIK3CD cDNA Clone (2)

NM_005026.3

クローニングベクター cDNA 製品

In lentiviral vector

PIK3CD の背景知識

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p11-alpha p11-beta, and p11-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.

PIK3CD の参考文献

  • Poopal AC, Schroeder LM, Horn PS, Bassell GJ, Gross C. Increased expression of the PI3K catalytic subunit p110δ underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family. Molecular Autism. 2016;7:3.

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