PHPT1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

PHPT1 (Phosphohistidine Phosphatase 1) is a protein coding gene located on human chromosome 9q34.3. PHPT1 is also known as PHP, PHP14, CGI-202, HSPC141, and HEL-S-132P. The human PHPT1 gene encodes a 13833 Da protein containing 125 amino acids. The PHPT1 protein is ubiquitously expressed in heart, prostate and other tissues. PHPT1 is related to ion channel binding and calcium channel inhibitor activity. PHPT1 is associated with Retinohepatoendocrinologic Syndrome.

PHPT1 Protein (1)

    PHPT1 Antibody (7)

      PHPT1 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      PHPT1 cDNA Clone (30)

      NM_014172.5

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_029293.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      PHPT1 qPCR Primer (1)

      PHPT1 の背景知識

      PHPT1, also known as 14 kDa phosphohistidine phosphatase, phosphohistidine phosphatase 1, protein janus-A homolog, PHP14, is a cytoplasm protein which belongs to the janus family. PHPT1 / PHP14 is expressed abundantly in heart and skeletal muscle. Phosphatases are a diverse group of enzymes that regulate numerous cellular processes. Much of what is known relates to the tyrosine, threonine, and serine phosphatases, whereas the histidine phosphatases have not been studied as much. Protein histidine phosphorylation exists widely in vertebrates, and it plays important roles in signal transduction and other cellular functions. Protein histidine phosphorylation accounts for about 6% of the total protein phosphorylation in eukaryotic cells. The knowledge about eukaryotic PHPT (protein histidine phosphatase) is still very limited. To date, only one vertebrate PHPT has been discovered, and two crystal structures of human PHPT1 have been solved. PHPT1 / PHP14 can dephosphorylate a variety of proteins (e.g. ATP-citrate lyase and the beta-subunit of G proteins). A putative active site has been identified by its electrostatic character, ion binding, and conserved protein residues.

      PHPT1 の参考文献

      • Busam,R.D. et al., 2006, J Biol Chem. 281 (45):33830-4.
      • Zhang,X.Q. et al., 2009, Ups J Med Sci.114 (2):65-72.
      • Gong,W. et al., 2009, Biochem J. 418 (2):337-44.
      • Chapin,L.J. et al., 2009, J Exp Bot. 60 (7):2179-90.

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