PHGDH Proteins, Antibodies, cDNA Clones Research Reagents

PHGDH (Phosphoglycerate Dehydrogenase) is a protein coding gene located on human chromosome 1p12. PHGDH is also known as NLS, PDG, PGD, NLS1, PGAD, PGDH, SERA, 3PGDH, 3-PGDH, PHGDHD and HEL-S-113. The human PHGDH gene encodes a 56651 Da protein containing 533 amino acids. Broad expression in fat (RPKM 36.0), skin (RPKM 33.6) and 23 other tissues Among its related pathways are One carbon pool by folate and Viral mRNA Translation. PHGDH is related to electron transfer activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. CTBP2 is an important paralog of PHGDH gene. PHGDH is associated with some diseases, including Phosphoglycerate Dehydrogenase Deficiency and Neu-Laxova Syndrome 1.

PHGDH Protein (1)

    PHGDH Antibody (7)

      PHGDH cDNA Clone (30)

      NM_006623.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      AK169684.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      PHGDH の背景知識

      PHGDH is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family. This new family consists of D-isomer-stereospecific enzymes. The conserved residues in this family appear to be the residues involved in the substrate binding and the catalytic reaction, and thus to be targets for site-directed mutagenesis. A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related. PHGDH catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor. Overexpression of PHGDH may cause certain breast cancers. Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency which is characterized by congenital microcephaly, psychomotor retardation, and seizures.

      PHGDH の参考文献

      • Pind S, et al. (2002) V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme. J Biol Chem. 277 (9): 7136-43.
      • Du H, et al. (2010) 3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells. Reproduction. 139 (1): 237-45.
      • Possemato R, et al. (2011) Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 476 (7360): 346-50.

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