PHB/Prohibitin Antibodies, cDNA Clones Research Reagents

PHB (Prohibitin, also known as PHB1; HEL-215; HEL-S-54e), located on 17q21.33, is a Protein Coding gene. This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. The gene produces a 29804 Da protein composed of 272 amino acids. PHB is a ubiquitous protein that is mainly localized in the inner mitochondrial membrane and exerts various mitochondrial functions. PHB might play important roles during spermatogenesis and oogenesis by regulating mitochondrial activities. Diseases such as Breast Cancer and Igg4-Related Disease are associated with PHB.

PHB/Prohibitin Antibody (2)

    PHB/Prohibitin cDNA Clone (46)

    NM_002634

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_008831.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_031851.2

    クローニングベクター cDNA 製品

    NM_001266323.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    PHB/Prohibitin qPCR Primer (1)

    PHB/Prohibitin の背景知識

    Prohibitin (PHB) is overtly conserved evolutionarily and ubiquitously expressed protein with pleiotropic functions in diverse cellular compartments. PHB is a ubiquitous protein that is mainly localized in the inner mitochondrial membrane and exerts various mitochondrial functions. PHB may be a substrate of poly-ubiquitin to regulate the ubiquitination of mitochondria and even subsequent elimination during P. esculenta spermiogenesis, and it has a potential role in guaranteeing the maternal inheritance of mitochondria. PHB might play important roles during spermatogenesis and oogenesis by regulating mitochondrial activities. There are several studies reported to understand and decipher PHB's role in diseases and/or cancers of ovary, lung, stomach, thyroid, liver, blood, prostate, gastric, esophagus, glioma, breast, bladder, etc. where PHB is shown to act through mechanisms by acting as an oncogene, tumor suppressor, antioxidant, antiapoptotic, in angiogenesis, autophagy, etc.

    PHB/Prohibitin の参考文献

    • Qiu X, et al. (2020) Characterization of phb in the gonadal development of the swimming crab portunus trituberculatus. Comp Biochem Physiol B Biochem Mol Biol 240 110338.
    • Hou CC, et al. (2018) The expression pattern and potential functions of phb in the spermiogenesis of phascolosoma esculenta. Gene 652 25-38.
    • Chowdhury D, et al. (2017) Phb in cardiovascular and other diseases: Present knowledge and implications. Curr Drug Targets 18 (16): 1836-1851.

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