PGM2/phosphoglucomutase 2 Antibodies, cDNA Clones Research Reagents

PGM2 (Phosphoglucomutase 2, also known as MSTP006), located on 4p14, is a Protein Coding gene. The gene produces a 68283 Da protein composed of 612 amino acids. The gene PGM2 encodes the last enzyme of the Leloir pathway, phosphoglucomutase 2 (Pgm2p), which catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. The PGM2 protein shares about 20% identity with mammalian PGM1. PGM2 may play a role in congenital immunodeficiencies. Diseases such as Melnick-Needles Syndrome and Otopalatodigital Syndrome Spectrum Disorder are associated with PGM2.

PGM2/phosphoglucomutase 2 Antibody (2)

    PGM2/phosphoglucomutase 2 cDNA Clone (17)

    BC010087

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_006250996.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    PGM2/phosphoglucomutase 2 qPCR Primer (1)

    PGM2/phosphoglucomutase 2 の背景知識

    The gene PGM2 encodes the last enzyme of the Leloir pathway, phosphoglucomutase 2 (Pgm2p), which catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. Overexpression of PGM2 has previously been shown to enhance the aerobic growth of S. cerevisiae in galactose medium. Overexpression of the PGM2 gene encoding phosphoglucomutase (Pgm2p) has been shown to improve galactose utilization both under aerobic and under anaerobic conditions. PGM2 overexpression in S. cerevisiae from an integrative plasmid is sufficient to reduce the lag phase and to enhance the growth rate in anaerobic galactose fermentation, which results in an overall decrease in fermentation duration. Deletion of PGM2 decreased cellular glucose-1-phosphate and overexpression of SNR84 increased the maltose permease activity.

    PGM2/phosphoglucomutase 2 の参考文献

    • Lin X, et al. (2015) Enhanced leavening ability of baker's yeast by overexpression of snr84 with pgm2 deletion. J Ind Microbiol Biotechnol 42 (6): 939-948.
    • Garcia Sanchez R, et al. (2010) Pgm2 overexpression improves anaerobic galactose fermentation in saccharomyces cerevisiae. Microb Cell Fact 9 40.
    • Garcia Sanchez R, et al. (2010) Cross-reactions between engineered xylose and galactose pathways in recombinant saccharomyces cerevisiae. Biotechnol Biofuels 3 19.

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