PFKM Proteins, cDNA Clones Research Reagents

PFKM (Phosphofructokinase, Muscle) is a protein coding gene located on human chromosome 12q13.11. PFKM is also known as GSD7, PFK1, PFKA, PFKX, PFK-1, PFK-A, ATP-PFK and PPP1R122. The human PFKM gene encodes an 85183 Da protein containing 780 amino acids. The PFKM protein is broadly expressed in heart, brain and other tissues. Among its related pathways are Glucose metabolism and Akt Signaling. PFKM is related to protein homodimerization activity and protein C-terminus binding. PFKP is an important paralog of PFKM gene. PFKM is associated with some diseases, including Glycogen Storage Disease Vii and Encephalopathy, Progressive, Early-Onset, With Episodic Rhabdomyolysis.

PFKM Protein (1)

    PFKM cDNA Clone (47)

    BC021203

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001163487.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001163488.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_005570698.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    PFKM Lysate (1)

      PFKM の背景知識

      PFK1, also known as PFKM, is a regulatory glycolytic enzyme. PFK1 converts fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. It is a muscle-type isozyme. There are three phosphofructokinase isozymes in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Mutations in PFK1 gene have been related to glycogen storage disease type VII, also identified as Tarui disease.

      PFKM の参考文献

      • Yamasaki T., et al.,(1991), Structure of the entire human muscle phosphofructokinase-encoding gene: a two-promoter system. Gene 104:277-282.
      • Sharma P.M., et al., (1989), Cloning and expression of a human muscle phosphofructokinase cDNA.Gene 77:177-183.
      • Nakajima H., et al.,(1987), Cloning of human muscle phosphofructokinase cDNA.FEBS Lett. 223:113-116.

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