PFKFB3 Proteins, Antibodies, cDNA Clones Research Reagents

PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) is a protein coding gene located on human chromosome 10p15.1. PFKFB3 is also known as PFK2, IPFK2 and iPFK-2. The human PFKFB3 gene encodes a 59609 Da protein containing 520 amino acids. The PFKFB3 protein is biasedly expressed in fat, bone marrow and other tissues. Among its related pathways are Akt Signaling and Fructose and mannose metabolism. PFKFB3 is related to 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. PFKFB2 is an important paralog of PFKFB3 gene. PFKFB3 is associated with some diseases, including Colon Adenocarcinoma and Colorectal Cancer 6.

PFKFB3 Protein (1)

    PFKFB3 Antibody (1)

      PFKFB3 cDNA Clone (15)

      BC040482

      クローニングベクター cDNA 製品

      In lentiviral vector

      PFKFB3 qPCR Primer (1)

      PFKFB3 Lysate (1)

        PFKFB3 の背景知識

        Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, is a potent activator of phosphofructokinase, which is a rate-limiting enzyme of glycolysis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Fructose 2,6-bisphosphate (Fru-2,6-BP) is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1), a rate-limiting enzyme and essential control point in glycolysis. The concentration of PFK2 depends on the activity of the bifunctional enzyme, 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase (PFK-2 / FBPase). PFK2 controls the glycolytic flux via the allosteric activator fructose 2,6-bisphosphate. Because of its proto-oncogenic character, the PFK-2/FBPase-2 of the PFKFB3 gene is assumed to play a critical role in tumorigenesis. The hypoxia-inducible form of 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase (PFKFB3) plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severely hypoxic conditions.

        PFKFB3 の参考文献

        • Kessler R, et al. (2008) 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is up-regulated in high-grade astrocytomas. J Neurooncol. 86(3):257-64.
        • Yalcin A, et al. (2009) Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases. J Biol Chem. 284(36):24223-32.
        • Atsumi T, et al. (2002) High expression of inducible 6-phosphofructo-2-kinase / fructose-2, 6-bisphosphatase (iPFK-2; PFKFB3) in human cancers. Cancer Res. 262(20): 5881-7.
        • Kim SG, et al. (2006) Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy. J Biol Chem. 281(5): 2939-44.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.