PFDN2 Proteins, Antibodies, cDNA Clones Research Reagents

PFDN2 (Prefoldin Subunit 2) is a protein coding gene located on human chromosome 1q23.3. PFDN2 is also known as PFD2. The human PFDN2 gene encodes a 16648 Da protein containing 154 amino acids. The PFDN2 protein is ubiquitously expressed in fat, brain and other tissues. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Metabolism of proteins. PFDN2 is related to unfolded protein binding and protein binding involved in protein folding. PFDN2 is associated with some diseases, including Peroneal Neuropathy and Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly.

PFDN2 Protein (1)

    PFDN2 Antibody (4)

      PFDN2 cDNA Clone (15)

      BC012464

      クローニングベクター cDNA 製品

      In lentiviral vector

      PFDN2 qPCR Primer (1)

      PFDN2 の背景知識

      PFD2, also known as PFDN2, belongs to the prefoldin beta subunit family. PFD2 is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. PFD2 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. PFD2 also binds to a nascent polypeptide chain and promotes folding in a setting in which there are many competing pathways for nonnative proteins.

      PFDN2 の参考文献

      • Gerhard DS, et al. (2004) The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. 14(10B):2121-7.
      • Bauch A, et al. (2004) A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol. 6(2):97-105.
      • Nogaj LA, et al. (2005) Cellular levels of glutamyl-tRNA reductase and glutamate-1-semialdehyde aminotransferase do not control chlorophyll synthesis in Chlamydomonas reinhardtii. Plant Physiol. 139(1):389-96.

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