PEX3 Antibodies, cDNA Clones Research Reagents

PEX3 (Peroxisomal Biogenesis Factor 3, also known as TRG18; PBD10A; PBD10B), located on 6q24.2, is a Protein Coding gene. The product of this gene is involved in peroxisome biosynthesis and integrity. The gene produces a 42140 Da protein composed of 373 amino acids. The deduced 373-amino acid protein shares 23% and 20% sequence identity with P. pastoris and S. cerevisiae Pex3, respectively. The S. cerevisiae Pex3 protein is a peroxisomal integral membrane protein required for peroxisome biogenesis and integrity. Diseases such as Peroxisome Biogenesis Disorder 10B and Peroxisome Biogenesis Disorder 10A are associated with PEX3.

PEX3 Antibody (1)

    PEX3 cDNA Clone (30)

    BC014551

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_019961.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    PEX3 の背景知識

    PEX3 is a peroxisomal membrane protein (PMP) that functions in the import of PMPs into the peroxisomal membrane and has been shown to interact with pexophagic receptor proteins during pexophagy in yeast. Thus, PEX3 is important not only for peroxisome biogenesis but also for peroxisome degradation. Pex3 is an evolutionarily conserved type III peroxisomal membrane protein required for peroxisome formation. It is inserted into the ER membrane and sorted via an ER subdomain (the peroxisomal ER, or pER) to peroxisomes. The human peroxins PEX3 and PEX19 play a central role in peroxisomal membrane biogenesis. The membrane-anchored PEX3 serves as the receptor for cytosolic PEX19, which in turn recognizes newly synthesized peroxisomal membrane proteins. After delivering these proteins to the peroxisomal membrane, PEX19 is recycled to the cytosol.

    PEX3 の参考文献

    • Yamashita S, et al. (2014) The membrane peroxin pex3 induces peroxisome-ubiquitination-linked pexophagy. Autophagy 10 (9): 1549-1564.
    • Soukupova M, et al. (1999) Identification and characterization of the human peroxin pex3. Eur J Cell Biol 78 (6): 357-374.
    • Fakieh MH, et al. (2013) Intra-er sorting of the peroxisomal membrane protein pex3 relies on its luminal domain. Biol Open 2 (8): 829-837.

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