Pentraxin 3 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

PTX3 (Pentraxin 3) is a protein coding gene located on human chromosome 3q25.32. PTX3 is also known as TSG-14 and TNFAIP5. The human PTX3 gene encodes a 41976 Da protein containing 381 amino acids. The PTX3 protein is biasedly expressed in bone marrow, appendix and other tissues. Among its related pathways are Innate Immune System and Lung fibrosis. PTX3 is related to virion binding and (1->3)-beta-D-glucan binding. NPTX2 is an important paralog of PTX3 gene. PTX3 is associated with some diseases, including Infectious Myocarditis and Takayasu Arteritis.

Pentraxin 3 Protein (1)

    Pentraxin 3 Antibody (6)

      Pentraxin 3 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      Pentraxin 3 cDNA Clone (13)

      NM_002852

      クローニングベクター cDNA 製品

      In lentiviral vector

      Pentraxin 3 qPCR Primer (1)

      Pentraxin 3 Lysate (1)

        Pentraxin 3 の背景知識

        Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.

        Pentraxin 3 の参考文献

        • Rolph,M.S. et al., 2002, Arterioscler Thromb Vasc Biol. 22 (5):e10-4.
        • Mantovani A., et al., 2003, Vaccine. 21:S43-S47.
        • Luchetti,M.M. et al., 2004, Clin Exp Rheumatol. 22 (3):S66-72.
        • Mantovani, A. et al., 2006, Vascul Pharmacol. 45 (5):326-30.
        • Inforzato A., et al., 2008, J. Biol. Chem. 283:10147-61.

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