PEA15 Antibodies, cDNA Clones Research Reagents

PEA15 (Proliferation And Apoptosis Adaptor Protein 15, also known as PED; MAT1; HMAT1; MAT1H; PEA-15; HUMMAT1H; PED-PEA15; PED/PEA15), located on 1q23.2, is a Protein Coding gene. This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The gene produces a 15040 Da protein composed of 130 amino acids. PEA15 is a small protein involved in many protein-protein interactions that modulate the function of some key cellular effectors involved in major cell functions, including apoptosis, proliferation, and glucose metabolism.

PEA15 Antibody (1)

    PEA15 cDNA Clone (17)

    NM_003768.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001013231.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    PEA15 qPCR Primer (1)

    PEA15 の背景知識

    Phosphoprotein enriched in astrocytes 15(PEA15) was initially identified in astrocytes. PEA15, also known as phosphoprotein enriched in diabetes (PED), is a small protein involved in many protein-protein interactions that modulate the function of some key cellular effectors involved in major cell functions, including apoptosis, proliferation, and glucose metabolism. In particular, PED/PEA15 interacts with the phospholipase D (PLD) isoforms 1 and 2 increasing protein kinase C-α isoform activity and affects both insulin-stimulated glucose transport and glucose-stimulated insulin secretion. PEA15 binds ERK and RSK2 and high PEA15 levels can impair ERK- and RSK2-dependent transcription. PEA15 expression also inversely correlates with cell motility and invasiveness. Phosphoprotein enriched in astrocytes 15 (PEA15) plays a multi-functional role in neuronal cell survival.

    PEA15 の参考文献

    • Xian F, et al. (2019) Overexpression of phosphoprotein enriched in astrocytes 15 reverses the damage induced by propofol in hippocampal neurons. Mol Med Rep 20 (2): 1583-1592.
    • Gawecka JE, et al. (2012) Pea15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma. Int J Cancer 131 (7): 1556-1568.
    • Farina B, et al. (2013) Molecular basis of the ped/pea15 interaction with the c-terminal fragment of phospholipase d1 revealed by nmr spectroscopy. Biochim Biophys Acta 1834 (8): 1572-1580.

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