PDXK Antibodies, cDNA Clones Research Reagents

PDXK (Pyridoxal Kinase, also known as PKH; PNK; HMSN6C; PRED79; C21orf97; HEL-S-1a; C21orf124), located on 21q22.3, is a Protein Coding gene. The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The gene produces a 35102 Da protein composed of 312 amino acids. PDXK belongs to the phosphotransferase family of enzymes. Diseases such as Neuropathy, Hereditary Motor And Sensory, Type Vic, With Optic Atrophy, and Polyneuropathy are associated with PDXK.

PDXK Antibody (1)

    PDXK cDNA Clone (15)

    BC000123

    クローニングベクター cDNA 製品

    In lentiviral vector

    PDXK qPCR Primer (1)

    PDXK の背景知識

    Pyridoxal kinase (PdxK, EC 2.7.1.35) is an important enzyme of the vitamin B6 salvage pathway which is required for phosphorylation of B6 vitamers. PDXK belongs to the phosphotransferase family of enzymes and catalyzes the conversion of the three active forms of vitamin B6, pyridoxine, pyridoxal, and pyridoxamine, to their phosphorylated forms and thereby plays a key role in pyridoxal 5'-phosphate salvage. Pyridoxal kinase (PDXK) catalyzes the phosphorylation of pyridoxal, pyridoxamine, and pyridoxine in the presence of ATP and Zn2+. This constitutes an essential step in the synthesis of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, a cofactor for over 140 enzymes. In Drosophila, mutations in the dPdxk gene cause chromosome aberrations (CABs) and increase glucose content in larval hemolymph. Both phenotypes are rescued by the expression of the wild type human PDXK counterpart.

    PDXK の参考文献

    • Tang L, et al. (2005) Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. J Biol Chem 280 (35): 31220-31229.
    • Mascolo E, et al. (2019) The expression of four pyridoxal kinase (pdxk) human variants in drosophila impacts on genome integrity. Sci Rep 9 (1): 14188.
    • Keller N, et al. (2020) Hereditary polyneuropathy with optic atrophy due to pdxk variant leading to impaired vitamin b6 metabolism. Neuromuscul Disord 30 (7): 583-589.
    • Deka G, et al. (2014) Successful data recovery from oscillation photographs containing strong polycrystalline diffraction rings from an unknown small-molecule contaminant: Preliminary structure solution of salmonella typhimurium pyridoxal kinase (pdxk). Acta Crystallogr F Struct Biol Commun 70 (Pt 4): 526-529.

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