PDS5A Antibodies, cDNA Clones Research Reagents

PDS5A (PDS5 Cohesin Associated Factor A, also known as PIG54; SCC112; SCC-112), located on 4p14, is a Protein Coding gene. The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The gene produces a 150830 Da protein composed of 1337 amino acids. PDS5A contains an N-terminal RhoGEF domain, a leucine zipper domain, an N-adaptin domain, an SKP1 domain, 3 PEST sequences, 6 nuclear localization signals, and 2 sites for tyrosine phosphorylation. Diseases such as Sc Phocomelia Syndrome and Warsaw Breakage Syndrome are associated with PDS5A.

PDS5A Antibody (1)

    PDS5A cDNA Clone (15)


    クローニングベクター cDNA 製品

    In lentiviral vector

    PDS5A qPCR Primer (1)

    PDS5A の背景知識

    PDS5, a cohesion protein, is important for proper chromosome segregation in lower organisms and has two homologs in vertebrates (PDS5A and PDS5B). The precocious dissociation of sisters 5A (Pds5A), also known as sister chromatid cohesion protein 112 is a nuclear protein, expressed from the S right through to the mitotic phase. It is highly conserved from yeast to man and plays a role in the establishment, maintenance, and dissolution of sister chromatid cohesion. The mutation of Pds5A orthologs in lower organisms results in chromosome missegregation, aneuploidy, and DNA repair defects. It is considered that such defects can cause either cell death or contribute to the development of cancer cells. Indeed, altered expression levels of Pds5A have been observed in tumors of the breast, kidney, esophagus, stomach, liver, and colon.

    PDS5A の参考文献

    • Zhang B, et al. (2009) Dosage effects of cohesin regulatory factor pds5 on mammalian development: Implications for cohesinopathies. PLoS One 4 (5): e5232.
    • Hagemann C, et al. (2011) The cohesin-interacting protein, precocious dissociation of sisters 5a/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors. Int J Mol Med 27 (1): 39-51.

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