PDPK1 Antibodies, cDNA Clones Research Reagents

PDPK1 (3-Phosphoinositide Dependent Protein Kinase 1, also known as PDK1; PDPK2; PDPK2P; PRO0461), located on 16p13.3, is a Protein Coding gene. The gene produces a 63152 Da protein composed of 556 amino acids. PDPK1, one of the members of an upregulated EGF-signaling network in LRCC, mediates resistance to gemcitabine, is found to be dysregulated in pancreas cancer specimens, and might be an attractive molecular target for combination therapy studies. Diseases such as Endometrial Cancer and Lung Cancer are associated with PDPK1.

PDPK1 Antibody (1)

    PDPK1 cDNA Clone (30)

    NM_002613.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_011062.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    PDPK1 の背景知識

    3-phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1), and the majority of its substrates, belong to the AGC family of kinases (related to cAMP-dependent protein kinase 1, cyclic Guanosine monophosphate-dependent protein kinase, and protein kinase C), and control a plethora of cellular processes, downstream either to PI3K or other pathways, such as RAS GTPase-MAPK (mitogen-activated protein kinase). PDPK1, one of the members of an upregulated EGF-signaling network in LRCC, mediates resistance to gemcitabine, is found to be dysregulated in pancreas cancer specimens, and might be an attractive molecular target for combination therapy studies. An increasing amount of evidence hints at PDPK1 as an intriguing and underexplored target for cancer therapy. Several reports show that PDK1 expression is dysregulated in multiple cancer types. Furthermore, PDK1 is implicated in signaling pathways frequently altered in cancer, such as PI3K/Akt, Ras/MAPK, and Myc.

    PDPK1 の参考文献

    • Li D, et al. (2018) Loss of pdpk1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells. BMC Cancer 18 (1): 772.
    • Gagliardi PA, et al. (2018) Pdk1: At the crossroad of cancer signaling pathways. Semin Cancer Biol 48 27-35.
    • Di Blasio L, et al. (2017) Serine/threonine kinase 3-phosphoinositide-dependent protein kinase-1 (pdk1) as a key regulator of cell migration and cancer dissemination. Cancers (Basel) 9 (3): 25.

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