PDLIM5 Antibodies, cDNA Clones Research Reagents

PDLIM5 (PDZ And LIM Domain 5, also known as L9; ENH; LIM; ENH1), located on 4q22.3, is a Protein Coding gene. The gene produces a 63945 Da protein composed of 596 amino acids. This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes.

PDLIM5 Antibody (1)

    PDLIM5 cDNA Clone (30)

    NM_006457.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001190853.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    PDLIM5 の背景知識

    DLIM5, a member of the Enigma subfamily of PDZ and LIM domain protein family, contains an N-terminal PDZ domain and three LIM domains at its C-terminus. PDZ and LIM domain 5 (PDLIM5) is a cytoskeleton-associated protein and has been shown to bind to a variety of proteins through its specific domain, thereby acting to regulate cell migration and tumor progression. Overexpression of PDLIM5 prevents hypoxia-induced pulmonary hypertension (PH), and deletion of PDLIM5 in smooth muscle cells enhances hypoxia-induced PH in vivo. The PDLIM5 (PDZ and LIM domain 5) gene has been genetically associated with mood disorders; its expression is upregulated in the postmortem brains of patients with bipolar disorder and downregulated in the peripheral lymphocytes of patients with major depression. Acute and chronic methamphetamine (METH) administration may model mania and the evolution of mania into psychotic mania or schizophrenia-like behavioral changes, respectively.

    PDLIM5 の参考文献

    • Owusu D, et al. (2017) Polymorphisms in pdlim5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension. J Psychiatr Res 84 27-34.
    • Liu X, et al. (2017) High expression of pdlim5 facilitates cell tumorigenesis and migration by maintaining ampk activation in prostate cancer. Oncotarget 8 (58): 98117-98134.
    • Horiuchi Y, et al. (2013) Experimental evidence for the involvement of pdlim5 in mood disorders in hetero knockout mice. PLoS One 8 (4): e59320.
    • Cheng H, et al. (2016) A high-throughput screening platform targeting pdlim5 for pulmonary hypertension. J Biomol Screen 21 (4): 333-341.

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