PDGFRA Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

PDGFRA (Platelet Derived Growth Factor Receptor Alpha) is a protein coding gene located on human chromosome 4q12. PDGFRA is also known as CD140A, PDGFR2 and PDGFR-2. The human PDGFRA gene encodes a 122670 Da protein containing 1089 amino acids. The PDGFRA protein is ubiquitously expressed in ovary, brain and other tissues. Among its related pathways are RET signaling and Phospholipase D signaling pathway. PDGFRA is related to protein homodimerization activity and protein kinase activity. ENSG00000282278 is an important paralog of PDGFRA gene. PDGFRA is associated with some diseases, including Gist-Plus Syndrome and Hypereosinophilic Syndrome, Idiopathic.

PDGFRA Protein (9)

    PDGFRA Antibody (12)

      PDGFRA ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      PDGFRA cDNA Clone (27)

      NM_006206.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_012802.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_015138691.1

      In expression vector

      PDGFRA qPCR Primer (2)

      PDGFRA Lysate (7)

        PDGFRA の背景知識

        PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.

        PDGFRA の参考文献

        • Oseini AM, et al. (2009) PDGFRalpha: a new therapeutic target in the treatment of hepatocellular carcinoma? Expert Opin Ther Targets. 13(4): 443-54.
        • Meister M, et al. (2009) Expression and mutational status of PDGFR in thymic tumours. Anticancer Res. 29(10): 4057-61.
        • Martinho O, et al. (2009) Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas. Br J Cancer. 101(6): 973-82.

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