PDGF-D Antibodies, cDNA Clones Research Reagents

PDGFD (Platelet Derived Growth Factor D) is a protein coding gene located on human chromosome 11q22.3. PDGFD is also known as IEGF, SCDGFB, MSTP036 and SCDGF-B. The human PDGFD gene encodes a 42848 Da protein containing 370 amino acids. The PDGFD protein is biasedly expressed in adrenal, ovary and other tissues. Among its related pathways are Phospholipase D signaling pathway and Signaling by GPCR. PDGFD is related to growth factor activity and platelet-derived growth factor receptor binding. PDGFC is an important paralog of PDGFD gene. PDGFD is associated with some diseases, including Obstructive Nephropathy and Familiar Ovarian Carcinoma.

PDGF-D Antibody (2)

    PDGF-D cDNA Clone (39)

    NM_033135.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_025208.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_027924.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    PDGF-D の背景知識

    Platelet-derived growth factor D (PDGF-D), also known as Iris-expressed growth factor, is a member of the PDGF/vascular endothelial growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. PDGF-D/PDGFD only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. The expression of PDGF-D/PDGFD in the eye is tissue-specific. In the anterior segment, it is localized to iris and ciliary body, whereas in the retina, PDGF-D/PDGFD is restricted to the outer plexiform layer. PDGF-D/PDGFD is present in aqueous humor but is not detectable in mature lens or in mouse lens-derived alphaTN4-1 cells. PDGF-D/PDGFD is highly expressed in human breast cancer and facilitates tumor growth and lymph node metastasis, making it a potential target in breast cancer. PDGF-D/PDGFD increases drug delivery and hence improves the efficacy of chemotherapy through vessel normalization. Intervention in the PDGF-D pathway in the eye, perhaps by antibody or blocking peptide, could be useful in the treatment of certain cataracts, including post-operative secondary cataract.

    PDGF-D の参考文献

    • Ray S, et al. (2005) Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation. J Biol Chem. 280(9): 8494-502.
    • Uutela M, et al. (2004) PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Blood. 104 (10): 3198-204.
    • Taneda S, et al. (2004) Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury. J Am Soc Nephrol. 14 (10): 2544-55.

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