PDGF-C Proteins, Antibodies, cDNA Clones Research Reagents

PDGFC (Platelet Derived Growth Factor C) is a protein coding gene located on human chromosome 4q32.1. PDGFC is also known as SCDGF and FALLOTEIN. The human PDGFC gene encodes a 39029 Da protein containing 345 amino acids. The PDGFC protein is ubiquitously expressed in endometrium, prostate and other tissues. Among its related pathways are Phospholipase D signaling pathway and Signaling by GPCR. PDGFC is related to protein homodimerization activity and platelet-derived growth factor receptor binding. PDGFD is an important paralog of PDGFC gene. PDGFC is associated with some diseases, including Milker's Nodule and Macular Degeneration, Age-Related, 1.

PDGF-C Protein (6)

    PDGF-C Antibody (1)

      PDGF-C cDNA Clone (41)


      クローニングベクター cDNA 製品

      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector

      PDGF-C Lysate (4)

        PDGF-C の背景知識

        PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma pathways. PDGF-C acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. PDGF-C appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. PDGF-C is involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs.

        PDGF-C の参考文献

        • Li X, et al. (2000) PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat Cell Biol. 2 (5): 302-9.
        • Ding H, et al. (2004) A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet. 36 (10): 1111-6.
        • Choi SJ, et al. (2009) The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with CL/P. European Journal of Human Genetics. 17 (11): 774-84.

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