PDE1C Proteins, Antibodies, cDNA Clones Research Reagents

PDE1C (Phosphodiesterase 1C) is a protein coding gene located on human chromosome 7p14.3. PDE1C is also known as Hcam3, DFNA74, hCam-3 and cam-PDE 1C. The human PDE1C gene encodes an 80760 Da protein containing 709 amino acids. The PDE1C protein is biasedly expressed in heart, brain and other tissues. Among its related pathways are DAG and IP3 signaling and Sweet Taste Signaling. PDE1C is related to calmodulin binding and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. PDE1A is an important paralog of PDE1C gene. PDE1C is associated with some diseases, including Deafness, Autosomal Dominant 74 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna.

PDE1C Protein (1)

    PDE1C Antibody (1)

      PDE1C cDNA Clone (15)


      クローニングベクター cDNA 製品

      In lentiviral vector

      PDE1C qPCR Primer (1)

      PDE1C Lysate (1)

        PDE1C の背景知識

        PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory. PDE1C has a high affinity for both cAMP and cGMP. It is expressed in several tissues, including brain and heart. As a cyclic nucleotide phosphodiesterase, PDE1C has a dual-specificity for the second messengers cAMP and cGMP.

        PDE1C の参考文献

        • Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.
        • Dolci S, et al. (2006) Subcellular localization and regulation of type-1C and type-5 phosphodiesterases. Biochem Biophys Res Commun. 341(3):837-46.
        • Vandeput F, et al.. (2007) Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes. Biochemistry. J Biol Chem. 282(45):32749-57.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.