PDAP1 Antibodies, cDNA Clones Research Reagents

PDAP1 (PDGFA Associated Protein 1, also known as PAP; PAP1; HASPP28), located on 7q22.1, is a Protein Coding gene. The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The gene produces a 20630 Da protein composed of 181 amino acids. PDAP1 enhanced PDGFA-stimulated cell growth in mouse fibroblasts but inhibited the mitogenic effect of PDGFB. The binding between PDGFA and PDAP1 is a low affinity/high capacity interaction.

PDAP1 Antibody (1)

    PDAP1 cDNA Clone (45)

    BC000684

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001033313.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001266283.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    PDAP1 の背景知識

    PDAP1 (PDGFA Associated Protein 1) is a Protein Coding gene. The PDAP1 gene, located on 7q22.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. PDAP1 is widely expressed in fat, colon, and other tissues, and protects mature B cells against chronic ISR activation, and ensures efficient antibody diversification by promoting their survival and optimal function. Among its related pathways are Tyrosine Kinases / Adaptors and Innate Immune System.

    PDAP1 の参考文献

    • Weston VJ, et al. (2018) Synergistic action of dual igf1/r and mek inhibition sensitizes childhood acute lymphoblastic leukemia (all) cells to cytotoxic agents and involves downregulation of stat6 and pdap1. Exp Hematol 63 52-63.e55.
    • Sharma VK, et al. (2016) Increased expression of platelet-derived growth factor associated protein-1 is associated with pdgf-b mediated glioma progression. Int J Biochem Cell Biol 78 194-205.
    • Delgado-Benito V, et al. (2020) Pdgfa-associated protein 1 protects mature b lymphocytes from stress-induced cell death and promotes antibody gene diversification. J Exp Med 217 (10): e20200137.

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