PCSK1 Proteins, Antibodies, cDNA Clones Research Reagents

PCSK1 (Proprotein Convertase Subtilisin/Kexin Type 1) is a protein coding gene located on human chromosome 5q15. PCSK1 is also known as PC1, PC3, NEC1, SPC3, and BMIQ12. The human PCSK1 gene encodes an 84152 Da protein containing 753 amino acids. The PCSK1 protein is biasedly expressed in brain, adrenal and other tissues. Among its related pathways are Neuroscience and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. PCSK1 is related to serine-type endopeptidase activity and endopeptidase activity. FURIN is an important paralog of PCSK1 gene. PCSK1 is associated with some diseases, including Proprotein Convertase 1/3 Deficiency and Body Mass Index Quantitative Trait Locus 12.

PCSK1 Protein (1)

    PCSK1 Antibody (3)

      PCSK1 cDNA Clone (28)

      NM_000439.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_013628.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      PCSK1 Lysate (1)

        PCSK1 の背景知識

        Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is an enzyme which belongs to the peptidase S8 family and Furin subfamily. PCSK1 is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleave after a single arginine. It binds to a protein known as proSAAS, which also represents its endogenous inhibitor. PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. PCSK1 substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Defects in PCSK1 are the cause of proprotein convertase 1 deficiency (PC1 deficiency). PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction. It is due to impaired processing of prohormones.

        PCSK1 の参考文献

        • Jackson RS. et al., 2003, J. Clin. Invest. 112:1550-60.
        • Farooqi I.S. et al., 2007, J. Clin. Endocrinol. Metab. 92: 3369-73.
        • Benzinou,M. et al., 2008,Nat Genet. 40 (8):943-5.
        • Benzinou M. et al., 2008, Nat. Genet. 40:943-5.
        • Renström F, et al., 2009, Hum. Mol. Genet. 18 (8): 1489-96.

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