PCDH18/Protocadherin 18 Antibodies Research Reagents

PCDH18 (Protocadherin 18, also known as PCDH68L), located on 4q28.3, is a Protein Coding gene. This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene produces a 126149 Da protein composed of 1135 amino acids. The deduced amino acid sequence of mPcdh18 contains six extracellular cadherin motifs, a single transmembrane region, and a large intracellular domain. mPcdh18 is present in a variety of tissues in the embryo, but in adult mice, it is primarily expressed in the lung and kidney.

PCDH18/Protocadherin 18 Antibody (1)

    PCDH18/Protocadherin 18 qPCR Primer (1)

    PCDH18/Protocadherin 18 の背景知識

    pcdh18 contains a motif (centered at Y842) shared with Src kinases (QGQYQP) that is required for the inhibitory phenotype. Thus, pcdh18 is a novel activation marker of CD8(+) memory T cells that can function as an inhibitory signaling receptor and restrict the effector phase. Mouse Pcdh18 (mPcdh18), which consists of four exons similar to other protocadherin family members, maps to chromosome 3. The deduced amino acid sequence of mPcdh18 contains six extracellular cadherin motifs, a single transmembrane region, and a large intracellular domain. The site of Disabled-1 (Dab1) interaction was localized to the C-terminal 243 residues of mPcdh18. Expression analyses revealed that mPcdh18 is present in a variety of tissues in the embryo, but in adult mice, it is primarily expressed in the lung and kidney. In the embryonic brain, mPcdh18 expression is temporally and spatially regulated.

    PCDH18/Protocadherin 18 の参考文献

    • Zhou D, et al. (2017) Pcdh18 is frequently inactivated by promoter methylation in colorectal cancer. Sci Rep 7 (1): 2819.
    • Vazquez-Cintron EJ, et al. (2012) Protocadherin-18 is a novel differentiation marker and an inhibitory signaling receptor for cd8+ effector memory t cells. PLoS One 7 (5): e36101.
    • Homayouni R, et al. (2001) Disabled-1 interacts with a novel developmentally regulated protocadherin. Biochem Biophys Res Commun 289 (2): 539-547.

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