PCBP4/MCG10 Antibodies, cDNA Clones Research Reagents

PCBP4 (Poly(RC) Binding Protein 4, also known as CBP; LIP4; MCG10), located on 3p21.2, is a Protein Coding gene. This gene encodes a member of the KH-domain protein subfamily. The gene produces a 41482 Da protein composed of 403 amino acids. PCBP4 plays a role in the cell cycle and is implicated in lung tumor suppression. PCBP4 also plays important role in the induction of cisplatin resistance in human maxillary cancers. It is a novel molecular target for the therapy of head and neck cancers, especially cisplatin-resistant cancers.

PCBP4/MCG10 Antibody (1)

    PCBP4/MCG10 cDNA Clone (31)

    NM_001174100.1

    In expression vector

    NM_021567.5

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001260867.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    PCBP4/MCG10 の背景知識

    Poly(C)-binding protein 4 (PCBP4), also known as MCG10, is an RBP belonging to the poly(C)-binding protein family and a target of p53 tumor suppressor. PCBP4 plays a role in the cell cycle and is implicated in lung tumor suppression. Ectopic expression of PCBP4 induces cell-cycle arrest in G₂ and apoptosis. PCBP4 regulates both basal and stress-induced p21 expression through binding p21 3'-UTR and modulating p21 mRNA stability. alpha CP-4 is an RNA-binding protein coded by PCBP4, a gene mapped to 3p21, a commonly deleted region in lung cancer. PCBP4 plays important role in the induction of cisplatin resistance in human maxillary cancers. PCBP4 is a novel molecular target for the therapy of head and neck cancers, especially cisplatin-resistant cancers.

    PCBP4/MCG10 の参考文献

    • Yan W, et al. (2016) Mice deficient in poly(c)-binding protein 4 are susceptible to spontaneous tumors through increased expression of zfp871 that targets p53 for degradation. Genes Dev 30 (5): 522-534.
    • Scoumanne A, et al. (2011) The cyclin-dependent kinase inhibitor p21 is regulated by rna-binding protein pcbp4 via mrna stability. Nucleic Acids Res 39 (1): 213-224.
    • Pio R, et al. (2004) Alpha cp-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha cp-4a, is underexpressed in lung cancer. Cancer Res 64 (12): 4171-4179.
    • Ito Y, et al. (2015) Suppression of poly(rc)-binding protein 4 (pcbp4) reduced cisplatin resistance in human maxillary cancer cells. Sci Rep 5 12360.

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