Parvin alpha/PARVA Proteins, Antibodies, cDNA Clones Research Reagents

PARVA (Parvin Alpha) is a protein coding gene located on human chromosome 11p15.3. PARVA is also known as MXRA2 and CH-ILKBP. The human PARVA gene encodes a 42244 Da protein containing 372 amino acids. The PARVA protein is ubiquitously expressed in endometrium, fat and other tissues. Among its related pathways are Focal Adhesion and ERK Signaling. PARVA is related to actin binding. PARVB is an important paralog of PARVA gene. PARVA is associated with some diseases, including Metagonimiasis and Breast Giant Fibroadenoma.

Parvin alpha/PARVA Protein (1)

    Parvin alpha/PARVA Antibody (3)

      Parvin alpha/PARVA cDNA Clone (15)

      BC016713

      クローニングベクター cDNA 製品

      In lentiviral vector

      Parvin alpha/PARVA qPCR Primer (1)

      Parvin alpha/PARVA の背景知識

      Actopaxin, also known as alpha-parvin, belongs to the parvin family. It is widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. Actopaxin contains 2 CH (calponin-homology) domains and probably plays a role in the regulation of cell adhesion and cytoskeleton organization. It interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Actopaxin binds directly to both F-actin and paxillin LD1 and LD4 motifs. Actopaxin also exhibits robust focal adhesion localization in several cultured cell types but is not found along the length of the associated actin-rich stress fibers. It is absent from actin-rich cell-cell adherens junctions.

      Parvin alpha/PARVA の参考文献

      • Korenbaum E, et al. (2002) Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. Gene. 279(1):69-79.
      • Nikolopoulos SN, et al. (2002) Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization. J Biol Chem. 277(2): 1568-75.
      • Tu Y, et al. (2001) A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading. J Cell Biol. 153(3): 585-98.

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