PARP16 Antibodies, cDNA Clones Research Reagents

PARP16 (Poly(ADP-Ribose) Polymerase Family Member 16, also known as ARTD15; pART15; C15orf30), located on 15q22.31, is a Protein Coding gene. The gene produces a 36383 Da protein composed of 322 amino acids. Human PARP16 (also known as ARTD15) is a tail-anchored ER transmembrane protein required for activation of the functionally related ER stress sensors PERK and IRE1α during the UPR. Modification of PERK and IRE1α by PARP16 increases their kinase activities and the endonuclease activity of IRE1α. Diseases such as Osebold-Remondini Syndrome and Arthrogryposis, Renal Dysfunction, And Cholestasis 1 are associated with PARP16.

PARP16 Antibody (1)

    PARP16 cDNA Clone (16)

    BC031074

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001014093.1

    In expression vector

    PARP16 qPCR Primer (1)

    PARP16 の背景知識

    PARP16, a mono-ADP-ribose transferase, has emerged as a potential therapeutic target. Human PARP16 (also known as ARTD15) is a tail-anchored ER transmembrane protein required for activation of the functionally related ER stress sensors PERK and IRE1α during the UPR. The third identified ER stress sensor, ATF6, is not regulated by PARP16. As is the case for other PARPs that function during stress, the enzymatic activity of PARP16 is upregulated during ER stress when it ADP-ribosylates itself, PERK and IRE1α. ADP-ribosylation by PARP16 is sufficient for activating PERK and IRE1α in the absence of ER stress and is required for PERK and IRE1α activation during the UPR. Modification of PERK and IRE1α by PARP16 increases their kinase activities and the endonuclease activity of IRE1α. The carboxy-terminal luminal tail of PARP16 is required for PARP16 function during ER stress, suggesting that it transduces stress signals to the cytoplasmic PARP catalytic domain.

    PARP16 の参考文献

    • Wang J, et al. (2017) Epigallocatechin-3-gallate enhances er stress-induced cancer cell apoptosis by directly targeting parp16 activity. Cell Death Discov 3 17034.
    • Jwa M, et al. (2012) Parp16 is a tail-anchored endoplasmic reticulum protein required for the perk- and ire1α-mediated unfolded protein response. Nat Cell Biol 14 (11): 1223-1230.

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