PARP Proteins, Antibodies, cDNA Clones Research Reagents

All PARP reagents are produced in house and quality controlled, including 4 PARP Antibody, 30 PARP Gene, 2 PARP IP Kit, 2 PARP Lysate, 2 PARP Protein, 2 PARP qPCR. All PARP reagents are ready to use.

PARP Protein (2)

    PARP Antibody (4)

      PARP cDNA Clone (30)


      クローニングベクター cDNA 製品

      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector

      PARP Lysate (2)

        PARP の背景知識

        Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of NAD+ is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 2-3 units. The poly(ADP-ribosyl)ation modification is critical for a wide range of processes, including DNA repair, regulation of chromosome structure, transcriptional regulation, mitosis and apoptosis. PARP1 is demonstrateed to mediate the poly(ADP-ribose) ation of APLF (aprataxin PNK-like factor) and CHFR (checkpoint protein with FHA and RING domains), two representative proteins involved in the DNA damage response and checkpoint regulation. Further, It has been suggested that DNA-dependent protein kinase (DNA-PK), another component of DNA repair, suppresses PARP activity, probably through direct binding and/or sequestration of DNA-ends which serve as an important stimulator for both enzymes. PARP1 inhibitors is thus proposed as a targeted cancer therapy for recombination deficient cancers, such as BRCA2 tumors.

        PARP の参考文献

        • Malanga M. et al., 1998, J Biol Chem. 273: 11839-11843.
        • Ariumi Y. et al., 1999, Oncogene. 18: 4616-4625.
        • Helleday T. et al., 2005, Cell Cycle. 4: 1176-1178.
        • Ahell I. et al., 2008, Nature. 451: 81-85.

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