PARK7/DJ-1 Proteins, Antibodies, cDNA Clones Research Reagents

PARK7 (Parkinsonism Associated Deglycase) is a protein coding gene located on human chromosome 1p36.23. PARK7 is also known as DJ1, DJ-1, GATD2 and HEL-S-67p. The human PARK7 gene encodes a 19891 Da protein containing 189 amino acids. The PARK7 protein is ubiquitously expressed in adrenal, thyroid and other tissues. Among its related pathways are Neuroscience and Androgen receptor signaling pathway. PARK7 is related to protein homodimerization activity and signaling receptor binding. PARK7 is associated with some diseases, including Parkinson Disease 7, Autosomal Recessive Early-Onset and Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1.

PARK7/DJ-1 Protein (1)

    PARK7/DJ-1 Antibody (3)

      PARK7/DJ-1 cDNA Clone (47)

      NM_001123377.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      BC008188

      In expression vector

      In lentiviral vector

      NM_020569.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001277250.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      PARK7/DJ-1 の背景知識

      Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). DJ-1/p53 interactions contribute to apoptosis resistance in clonal myeloid cells and may serve as a prognostic marker in patients with myelodysplastic syndromes (MDS). DJ-1 regulates redox signaling kinase pathways and acts as a transcriptional regulator of antioxidative gene batteries. Therefore, DJ-1 is an important redox-reactive signaling intermediate controlling oxidative stress after ischemia, upon neuroinflammation, and during age-related neurodegenerative processes. Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke.

      PARK7/DJ-1 の参考文献

      • Takahashi K, et al. (2001). DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J. Biol. Chem. (United States). 276 (40): 37556-63.
      • Niki, Takeshi, et al. (2003). DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Mol. Cancer Res. (United States). 1 (4): 247-61.
      • Kahle PJ, et al. (2009) DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. Free Radic Biol Med. 47(10): 1354-61.
      • Xu X, et al. (2010) The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage. Blood Cells Mol Dis. 45(3): 227-32.
      • Marcondes AM, et al. (2010) Identification of DJ-1/PARK-7 as a determinant of stroma-dependent and TNF-alpha-induced apoptosis in MDS using mass spectrometry and phosphopeptide analysis. Blood. 115(10): 1993-2002.

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