PARD6B Antibodies, cDNA Clones Research Reagents

PARD6B (Par-6 Family Cell Polarity Regulator Beta, also known as PAR6B), located on 20q13.13, is a Protein Coding gene. This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain, and a semi-Cdc42/Rac interactive binding (CRIB) domain. The gene produces a 41182 Da protein composed of 372 amino acids. The protein contains a central CRIB motif and a PDZ domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.

PARD6B Antibody (1)

    PARD6B cDNA Clone (13)

    BC060847

    クローニングベクター cDNA 製品

    In lentiviral vector

    PARD6B qPCR Primer (1)

    PARD6B の背景知識

    PARD6B (Par-6 Family Cell Polarity Regulator Beta) is a Protein Coding gene. The PARD6B gene, located on 20q13.13, is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, zebrafish, and frog. This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain, and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. PARD6B is widely expressed in the kidney, lung, and other tissues. Among its related pathways are G-protein signaling RAC1 in the cellular process and Ras signaling pathway. An important paralog of this gene is PARD6G.

    PARD6B の参考文献

    • Yosifova A, et al. (2011) Genome-wide association study on bipolar disorder in the bulgarian population. Genes Brain Behav 10 (7): 789-797.
    • Michaux G, et al. (2016) The localisation of the apical par/cdc42 polarity module is specifically affected in microvillus inclusion disease. Biol Cell 108 (1): 19-28.
    • Durgan J, et al. (2011) Par6b and atypical pkc regulate mitotic spindle orientation during epithelial morphogenesis. J Biol Chem 286 (14): 12461-12474.

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