PANP/C12orf53 Proteins, cDNA Clones Research Reagents

PIANP (PILR Alpha Associated Neural Protein) is a protein coding gene located on human chromosome 12p13.31. PIANP is also known as PANP, LEDA1, leda-1 and C12orf53. The human PIANP gene encodes a 30076 Da protein containing 282 amino acids. The PIANP protein is biasedly expressed in brain, endometrium and other tissues. PIANP is associated with some diseases, including Laurence-Moon Syndrome and Retinitis Pigmentosa 17.

PANP/C12orf53 Protein (1)

    PANP/C12orf53 cDNA Clone (14)

    BC035736

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001244014.1

    In expression vector

    PANP/C12orf53 qPCR Primer (1)

    PANP/C12orf53 Lysate (1)

      PANP/C12orf53 の背景知識

      C12orf53 is mainly expressed in adult brain and cerebellum. It also can be detected in fetal brain and virtually no expression in spleen, heart, kidney, liver and dorsal ganglion relative to brain. C12orf53 acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation. Chromosome 12 encodes over 1,100 genes within 132 million bases. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC class I interaction.

      PANP/C12orf53 の参考文献

      • Strausberg RL, et al. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.
      • Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Tissue Antigens. Nat Genet. 36(1):40-5.
      • Kogure A, et al. (2011) PANP is a novel O-glycosylated PILR ligand expressed in neural tissues. Biochem Biophys Res Commun. 405(3):428-33.

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