PAM Proteins, cDNA Clones Research Reagents

PAM (Peptidylglycine Alpha-Amidating Monooxygenase) is a protein coding gene located on human chromosome 5q21.1. PAM is also known as PAL and PHM. The human PAM gene encodes a 108332 Da protein containing 973 amino acids. The PAM protein is broadly expressed in heart, adrenal and other tissues. PAM is related to copper ion binding and L-ascorbic acid binding. PAM is associated with some diseases, including Menkes Disease and Gestational Trophoblastic Neoplasm.

PAM Protein (2)

    PAM cDNA Clone (13)


    クローニングベクター cDNA 製品

    In lentiviral vector

    PAM qPCR Primer (1)

    PAM Lysate (2)

      PAM の背景知識

      Peptidylglycine alpha-amidating monooxygenase (PAM) is highly expressed in neurons and endocrine cells, where it catalyzes one of the final steps in the biosynthesis of bioactive peptides. PAM is also expressed in unicellular organisms such as Chlamydomonas reinhardtii, which do not store peptides in secretory granules. As for other granule membrane proteins, PAM is retrieved from the cell surface and returned to the trans-Golgi network. This pathway involves regulated entry of PAM into multivesicular body intralumenal vesicles (ILVs). Peptidylglycine alpha-amidating monooxygenase (PAM) is an essential enzyme that catalyzes the COOH-terminal amidation of many neuroendocrine peptides.

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