PALM/Paralemmin Antibodies, cDNA Clones Research Reagents

PALM (Paralemmin, also known as PALM1), located on 19p13.3, is a Protein Coding gene. The gene produces a 42076 Da protein composed of 387 amino acids. The protein is a member of the paralemmin protein family. PALM is a phosphoprotein associated with brain synaptic plasma membranes. It is also abundant in several endocrine tissues and appears to affect cell shape through a C-terminal lipid anchor. Diseases such as Waardenburg Syndrome, Type 2B, and Osteopetrosis, Autosomal Dominant 2 are associated with PALM.

PALM/Paralemmin Antibody (1)

    PALM/Paralemmin cDNA Clone (28)


    クローニングベクター cDNA 製品

    In lentiviral vector


    クローニングベクター cDNA 製品

    In lentiviral vector

    PALM/Paralemmin の背景知識

    Paralemmin (Palm) is a prenyl-palmitoyl anchored membrane protein that can drive membrane and process formation in neurons. Earlier studies have shown brain preferred Palm expression, although this protein is a major water-insoluble protein in chicken lens fiber cells and the Palm gene may be regulated by Pax6. Paralemmin has been implicated as a potent modulator of cellular cAMP signaling within the brain. It is abundant in the brain, is expressed at intermediate levels in the kidney and endocrine cells, and occurs at low levels in many other tissues. Diseases associated with PALM include Waardenburg Syndrome, Type 2B, and Osteopetrosis, Autosomal Dominant 2. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

    PALM/Paralemmin の参考文献

    • Castellini M, et al. (2005) Palm is expressed in both developing and adult mouse lens and retina. BMC Ophthalmol 5 14.
    • Burwinkel B, et al. (1998) Structure of the human paralemmin gene (palm), mapping to human chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding mutations in grizzled, mocha, jittery, and hesitant mice. Genomics 49 (3): 462-466.
    • Basile M, et al. (2006) Paralemmin interacts with d3 dopamine receptors: Implications for membrane localization and camp signaling. Arch Biochem Biophys 446 (1): 60-68.

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