Paralemmin (Palm) is a prenyl-palmitoyl anchored membrane protein that can drive membrane and process formation in neurons. Earlier studies have shown brain preferred Palm expression, although this protein is a major water-insoluble protein in chicken lens fiber cells and the Palm gene may be regulated by Pax6. Paralemmin has been implicated as a potent modulator of cellular cAMP signaling within the brain. It is abundant in the brain, is expressed at intermediate levels in the kidney and endocrine cells, and occurs at low levels in many other tissues. Diseases associated with PALM include Waardenburg Syndrome, Type 2B, and Osteopetrosis, Autosomal Dominant 2. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.