PAK3 Proteins, cDNA Clones Research Reagents

PAK3 (P21 (RAC1) Activated Kinase 3) is a protein coding gene located on human chromosome Xq23. PAK3 is also known as ARA, bPAK, MRX30, MRX47, OPHN3, PAK-3, PAK3beta and beta-PAK. The human PAK3 gene encodes a 62310 Da protein containing 559 amino acids. The PAK3 protein is biasedly expressed in brain, pancreas and other tissues. Among its related pathways are Semaphorin interactions and Integrin Pathway. PAK3 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. PAK1 is an important paralog of PAK3 gene. PAK3 is associated with some diseases, including Non-Syndromic X-Linked Intellectual Disability and Microcephaly.

PAK3 Protein (1)

    PAK3 cDNA Clone (2)

    NM_001128166.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    PAK3 qPCR Primer (1)

    PAK3 Lysate (1)

      PAK3 の背景知識

      PAK3 is a member of PAK proteins, a family of serine/threonine p21-activating kinases, serve as effectors of small Rho GTPases Cdc42 and RAC and have been implicated in a wide range of biological activities. There are six mammalian PAKs which can be divided into two groups: group I PAKs (PAK1-3) and group II PAKs (PAK4-6). Although the two PAK groups are architecturally similar there are differences in their mode of regulation suggesting their cellular functions are likely to be different. Group I p21-activated kinases (PAK1/2/3) is demonstrated as ERK3/ERK4 activation loop kinases. It has been shown that group I PAKs phosphorylate ERK3 and ERK4 on Ser-189 and Ser-186, respectively, both in vitro and in vivo, and that expression of activated Rac1 augments this response. Besides regulation enzymatic activation of ERK3/ERK4, PAKs can also play roles in downstream activation of MAP kinase-activated protein kinase 5 (MK5) in vivo. Thus, the group I PAKs act as upstream activators of ERK3 and ERK4 and unravel a novel PAK-ERK3/ERK4-MK5 signaling pathway. In clinical, PAK has been proposed as a potential therapeutic target in schwannomas.

      PAK3 の参考文献

      • Whale A, et al. (2011) Signalling to cancer cell invasion through PAK family kinases. Front Biosci. 16: 849-64.
      • Deleris P, et al. (2011) Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. J Biol Chem. 286 (8): 6470-8.
      • Canet B, et al. (2011) Ovarian clear cell carcinomas: RHO GTPases may contribute to explain their singular biologic behavior. Hum Pathol. 42 (6): 833-9.

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