PACSIN3 (Protein Kinase C And Casein Kinase Substrate In Neurons 3) is a Protein Coding gene. The PACSIN3 gene, located on 11p11.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. Diseases associated with PACSIN3 include Hereditary Motor And Sensory Neuropathy, Type Iic and Metatropic Dysplasia. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. PACSIN3 has been shown to interact with PACSIN1 and PACSIN2.