PACSIN2 Antibodies, cDNA Clones Research Reagents

PACSIN2 (Protein Kinase C And Casein Kinase Substrate In Neurons 2, also known as SDPII), located on 22q13.2, is a Protein Coding gene. This gene is a member of the protein kinase C and casein kinase substrate in neurons family. PACSIN2 produces a 55739 Da protein composed of 486 amino acids. The PACSIN2 proteins contain a CDC15 N-terminal domain, a C-terminal SRC homology-3 (SH3) domain, 3 conserved regions specific to the PACSIN family, and 3 Asn-Pro-Phe (NPF) motifs, which potentially bind to EH domains. Diseases such as Thiopurines, Poor Metabolism Of, 1, and Skin Angiosarcoma are associated with PACSIN2.

PACSIN2 Antibody (1)

    PACSIN2 cDNA Clone (15)


    クローニングベクター cDNA 製品

    In lentiviral vector

    PACSIN2 qPCR Primer (1)

    PACSIN2 の背景知識

    PACSIN2/Syndapin II is one of the BAR domain-containing proteins and is localized at the necks of caveolae. PACSIN2 is thought to function in the scission and stabilization of caveolae, through binding to dynamin-2 and EHD2, respectively. These two functions are considered to be switched by PACSIN2 phosphorylation by protein kinase C (PKC) upon hypotonic stress and shear stress. The PACSIN2 phosphorylation decreases its membrane-binding activity, thereby decreasing its stabilizing effect on caveolae and triggering dynamin-mediated removal of caveolae. The F-BAR protein PACSIN2 is one of the most abundant BAR/F-BAR proteins in platelets and the only one reported to interact with the cytoskeletal and scaffold protein filamin A (FlnA), an essential regulator of platelet formation and function. Protein interaction between NS5A and PACSIN2 was confirmed by pulldown assay and further verified by both coimmunoprecipitation and immunofluorescence assays.

    PACSIN2 の参考文献

    • Senju Y, et al. (2015) Possible regulation of caveolar endocytosis and flattening by phosphorylation of f-bar domain protein pacsin2/syndapin ii. Bioarchitecture 5 (5-6): 70-77.
    • Senju Y, et al. (2015) Phosphorylation of pacsin2 by protein kinase c triggers the removal of caveolae from the plasma membrane. J Cell Sci 128 (15): 2766-2780.
    • Nguyen LP, et al. (2020) Pacsin2 interacts with nonstructural protein 5a and regulates hepatitis c virus assembly. J Virol 94 (5): e01531-19.
    • Begonja AJ, et al. (2015) Flna binding to pacsin2 f-bar domain regulates membrane tubulation in megakaryocytes and platelets. Blood 126 (1): 80-88.

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