PACSIN1 Antibodies, cDNA Clones Research Reagents

PACSIN1 (Protein Kinase C And Casein Kinase Substrate In Neurons 1) is a protein coding gene located on human chromosome 6p21.31. PACSIN1 is also known as SDPI. The human PACSIN1 gene encodes a 50966 Da protein containing 444 amino acids. The PACSIN1 protein is biasedly expressed in brain and lymph node. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. PACSIN1 is related to phospholipid binding and cytoskeletal protein binding. PACSIN2 is an important paralog of PACSIN1 gene. PACSIN1 is associated with some diseases, including Autosomal Recessive Non-Syndromic Intellectual Disability.

PACSIN1 Antibody (1)

    PACSIN1 cDNA Clone (15)


    クローニングベクター cDNA 製品

    In lentiviral vector

    PACSIN1 qPCR Primer (1)

    PACSIN1 の背景知識

    PACSIN1 is an important Tau binding partner in regulating microtubule dynamics and forming axonal plasticity.PACSIN1 interacts with Tau in axon. PACSIN1 blockade results in impaired axonal elongation and a higher number of primary axonal branches in mouse dorsal root ganglia neurons, which is induced by increasing the binding ability of Tau to microtubules. In PACSIN1-blocked dorsal root ganglia neurons, a greater amount of Tau is inclined to accumulate in the central domain of growth cones, and it promotes the stability of the microtubule network.

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