P4HB Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

P4HB (Prolyl 4-Hydroxylase Subunit Beta) is a protein coding gene located on human chromosome 17q25.3. P4HB is also known as DSI, GIT, PDI, PHDB, PDIA1, PO4DB, PO4HB, PROHB, CLCRP1, ERBA2L and P4Hbeta. The human P4HB gene encodes a 57116 Da protein containing 508 amino acids. The P4HB protein is ubiquitously expressed in duodenum, liver and other tissues. Among its related pathways are Lipoprotein metabolism and Signaling by GPCR. P4HB is related to protein heterodimerization activity. PDIA2 is an important paralog of P4HB gene. P4HB is associated with some diseases, including Cole-Carpenter Syndrome 1 and Cole-Carpenter Syndrome.

P4HB Protein (2)

    P4HB Antibody (15)

      P4HB ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      P4HB cDNA Clone (26)

      NM_000918.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_011032.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      P4HB Lysate (2)

        P4HB の背景知識

        Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase family. P4HB is highly abundant. In some cell types, it seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. P4HB localizes near CD4-enriched regions on lymphoid cell surfaces. It is identified by mass spectrometry in melanosome fractions from stage I to stage IV. P4HB reduces and may activate fusogenic properties of HIV-1 gp12 surface protein, thereby enabling HIV-1 entry into the cell. P4HB catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, it seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. P4HB may therefore cause structural modifications of exofacial proteins. Inside the cell, it seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, P4HB functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). P4HB may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.

        P4HB の参考文献

        • Kivirikko KI, et al., 1989, FASEB J., 3 (5): 1609-17.
        • Pihlajaniemi T, et al.,1991, J Hepatol., 13, Suppl 3: S2
        • Fenouillet E., et al., 2001, J. Infect. Dis. 183:744-752.
        • Gevaert K., et al., 2003, Nat. Biotechnol. 21:566-569.
        • Barbouche R., et al., 2003, J. Biol. Chem. 278:3131-3136.

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