P2RY6 Antibodies, cDNA Clones Research Reagents

P2RY6 (Pyrimidinergic Receptor P2Y6, also known as P2Y6), located on 11q13.4, is a Protein Coding gene. The gene produces a 36429 Da protein composed of 328 amino acids. The product of this gene belongs to the family of P2 receptors, which are activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Diseases such as RET signaling and Signaling by GPCR are associated with P2RY6.

P2RY6 Antibody (1)

    P2RY6 cDNA Clone (14)

    NM_001277204.1

    In expression vector

    NM_183168.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    P2RY6 qPCR Primer (1)

    P2RY6 の背景知識

    P2RY6 (Pyrimidinergic Receptor P2Y6) is a Protein Coding gene. The P2RY6 gene, located on 11q13.4, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish. The product of this gene belongs to the family of P2 receptors, which are activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Among its related pathways are RET signaling and Signaling by GPCR.

    P2RY6 の参考文献

    • Obba S, et al. (2015) The prkaa1/ampkα1 pathway triggers autophagy during csf1-induced human monocyte differentiation and is a potential target in cmml. Autophagy 11 (7): 1114-1129.
    • Nakano M, et al. (2017) Udp/p2y6 receptor signaling regulates ige-dependent degranulation in human basophils. Allergol Int 66 (4): 574-580.
    • Hao Y, et al. (2014) P2y6 receptor-mediated proinflammatory signaling in human bronchial epithelia. PLoS One 9 (9): e106235.

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