P2RY6 (Pyrimidinergic Receptor P2Y6) is a Protein Coding gene. The P2RY6 gene, located on 11q13.4, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish. The product of this gene belongs to the family of P2 receptors, which are activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Among its related pathways are RET signaling and Signaling by GPCR.