OXSR1 Proteins, cDNA Clones Research Reagents

OXSR1 (Oxidative Stress Responsive Kinase 1) is a protein coding gene located on human chromosome 3p22.2. OXSR1 is also known as OSR1. The human OXSR1 gene encodes a 58022 Da protein containing 527 amino acids. The OXSR1 protein is ubiquitously expressed in esophagus, bone marrow and other tissues. Among its related pathways are Cytoskeletal Signaling and Diuretics Pathway, Pharmacodynamics. OXSR1 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. STK39 is an important paralog of OXSR1 gene. OXSR1 is associated with some diseases, including Hypomagnesemia 4, Renal and Hypomagnesemia 3, Renal.

OXSR1 Protein (1)

    OXSR1 cDNA Clone (30)

    NM_005109.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_133985.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    OXSR1 Lysate (1)

      OXSR1 の背景知識

      Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. OXSR1 is a 58 kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines. The amino acid (aa) sequence of the predicted OXSR1 protein is 39% identical to that of human SOK1. Of potential regulators surveyed, endogenous OXSR1 is activated only by osmotic stresses, notably sorbitol and to a lesser extent NaCl. OXSR1 did not increase the activity of coexpressed JNK, nor did it activate three other MAPKs, p38, ERK2, and ERK5. Phosphorylation by OXSR1 modulates the G protein sensitivity of PAK isoforms. The OXSR1 and SPAK are key enzymes in a signalling cascade regulating the activity of Na+/K+/2Cl- co-transporters (NKCCs) in response to osmotic stress. Both kinases have a conserved carboxy-terminal (CCT) domain, which recognizes a unique peptide (Arg-Phe-Xaa-Val) motif. The OXSR1 and SPAK kinases specifically recognize their upstream activators and downstream substrates.

      OXSR1 の参考文献

      • Tamari M., et al.,(1999), Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3. J. Hum. Genet. 44:116-120.
      • Kikuno R., et al., (1999), Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.DNA Res. 6:197-205.
      • Chen W., et al.,(2004), Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.J. Biol. Chem. 279:11129-11136.

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