OSTM1 Proteins, Antibodies, cDNA Clones Research Reagents

OSTM1 (Osteoclastogenesis Associated Transmembrane Protein 1) is a protein coding gene located on human chromosome 6q21. OSTM1 is also known as GL, GIPN, OPTB5 and HSPC019. The human OSTM1 gene encodes a 37257 Da protein containing 334 amino acids. The OSTM1 protein is ubiquitously expressed in fat, adrenal and other tissues. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. OSTM1 is associated with some diseases, including Osteopetrosis, Autosomal Recessive 5 and Infantile Osteopetrosis With Neuroaxonal Dysplasia.

OSTM1 Protein (2)

    OSTM1 Antibody (5)

      OSTM1 cDNA Clone (26)


      クローニングベクター cDNA 製品

      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector

      OSTM1 Lysate (2)

        OSTM1 の背景知識

        Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 association with CLCN7 demonstrated that OSTM1 requires CLCN7 to localize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for osteoclast activation. Thus, OSTM1 has an important role in osteoclast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to osteoclast lineage, OSTM1-defect patients display the most severe recessive osteopetrosis phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO).

        OSTM1 の参考文献

          1.  Chalhoub, N. et al., 2003, Nat Med. 9 (4): 399-406.

          2.  Quarello, P. et al., 2004, J Bone Miner Res. 19 (7): 1194-1199.

          3.  Lange, PF. et al., 2006, Nature. 440 (7081): 220-223

          4.  Maranda, B. et al., 2008, J Bone Miner Res. 23 (2): 296-300.

          5.  Feigin, ME.et al., 2008, Cell Signal. 20 (5): 949-957.  

          6.  Pata, M.et al., 2008, J Biol Chem. 283 (45): 30522-30530. 

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