OSTF1 Antibodies, cDNA Clones Research Reagents

OSTF1 (Osteoclast Stimulating Factor 1, also known as OSF; SH3P2; bA235O14.1), located on 9q21.13, is a Protein Coding gene. The gene produces a 23787 Da protein composed of 214 amino acids. It contains an N-terminal proline-rich region and a potential N-glycosylation site but lacks a signal sequence. OSTF1 has ankyrin repeats and an Src homology-3 (SH3) domain that is homologous to the SH3 domain of GRB2 and FYN. OSTF1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption. Diseases such as Narcissistic Personality Disorder and Stork Bite are associated with OSTF1.

OSTF1 Antibody (1)

    OSTF1 cDNA Clone (18)

    NM_012383.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_017375.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_148892.3

    クローニングベクター cDNA 製品

    OSTF1 の背景知識

    OSTF1 (Osteoclast Stimulating Factor 1) is a Protein Coding gene. The OSTF1 gene, located on 9q21.13, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog. Ostf1 was first discovered by subtractive hybridization in the gills of Mozambique tilapia (Oreochromis mossambicus) transferred from Freshwater (FW) to seawater (SW). OSTF1 is an SH3 domain-containing protein that was initially identified as a factor involved in the indirect activation of osteoclasts. It has been linked to spinal muscular atrophy in humans through its interaction with SMN1 and is one of six genes deleted in a human developmental microdeletion syndrome. Diseases associated with OSTF1 include Narcissistic Personality Disorder and Stork Bite. Among its related pathways is the Innate Immune System.

    OSTF1 の参考文献

    • Vermeren M, et al. (2017) Osteoclast stimulation factor 1 (ostf1) knockout increases trabecular bone mass in mice. Mamm Genome 28 (11-12): 498-514.
    • Tse WK, et al. (2012) Eel osmotic stress transcriptional factor 1 (ostf1) is highly expressed in gill mitochondria-rich cells, where erk phosphorylated. Front Zool 9 (1): 3.
    • Tse WK (2014) The role of osmotic stress transcription factor 1 in fishes. Front Zool 11 (1): 86.

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