Osteomodulin Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

OMD (Osteomodulin, also known as OSAD; SLRR2C), located on 9q22.31, is a Protein Coding gene. The gene produces a 49492 Da protein composed of 421 amino acids. OMD is a keratan sulfate proteoglycan that promotes cell attachment and regulates the extracellular matrix during bone formation. OMD may play an important role during tooth development and biomineralization of dentin. Diseases such as Oromandibular Dystonia and Occult Macular Dystrophy are associated with OMD. The related pathways of OMD include Keratan sulfate/keratin metabolism and Metabolism.

Osteomodulin Protein (2)

    Osteomodulin Antibody (7)

      Osteomodulin ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      Osteomodulin cDNA Clone (25)


      クローニングベクター cDNA 製品

      In lentiviral vector


      Osteomodulin Lysate (2)

        Osteomodulin の背景知識

        Osteomodulin (OMD), also known as Osteoadherin (OSAD), Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, and SLRR2C, is a secreted protein that belongs to the small leucine-rich proteoglycan (SLRP) family and Class II subfamily. SLRP family proteins are normally found in extracellular matrices, but Osteomodulin is the only member restricted to mineralized tissues. Osteomodulin is primarily expressed by osteoblasts and might have a role in the regulation of mineralization. In bone, OSAD has been localized in the primary spongiosa within the bovine fetal rib growth plate. Moreover, in situ hybridization has shown expression of OSAD in osteoblasts close to the cartilage and bone border in the growth plate of rat femur. OSAD may play an important role during tooth development and biomineralization of dentin. Osteomodulin is a cell binding keratan sulfate proteoglycan that was recently isolated from mineralized bovine bone and subsequently cloned and sequenced. Osteomodulin may be implicated in biomineralization processes. It has a function in the binding of osteoblasts via the alpha (V) beta (3)-integrin. Osteomodulin is likely an osteoblast maturation marker that is induced by osteoclast activity. Osteomodulin is also an early marker for terminally differentiated matrix producing osteoblasts.

        Osteomodulin の参考文献

        • Buchaille R, et al. (2000) Expression of the small leucine-rich proteoglycan osteoadherin/osteomodulin in human dental pulp and developing rat teeth. Bone. 27(2): 265-70.
        • Petersson U, et al. (2003) Identification, distribution and expression of osteoadherin during tooth formation. Eur J Oral Sci. 111(2): 128-36.
        • Rehn AP, et al. (2006) Differential regulation of osteoadherin (OSAD) by TGF-beta1 and BMP-2. Biochem Biophys Res Commun. 349(3): 1057-64.

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