ORP150 Proteins, Antibodies, cDNA Clones Research Reagents

HYOU1 (Hypoxia Up-Regulated 1, also known as IMD59; Grp170; HSP12A; ORP150; GRP-170; ORP-150), located on 11q23.3, is a Protein Coding gene. The gene produces a 111335 Da protein composed of 999 amino acids. HYOU1 plays an important role in protein folding and secretion in the ER, perhaps as a molecular chaperone in concert with other GRPs, to cope with environmental stress. HYOU1 has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Diseases such as Immunodeficiency 59 And Hypoglycemia and Hypoxia are associated with HYOU1.

ORP150 Protein (1)

    ORP150 Antibody (3)

      ORP150 cDNA Clone (13)

      NM_001130991.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      ORP150 qPCR Primer (1)

      ORP150 Lysate (1)

        ORP150 の背景知識

        Hypoxia up-regulated protein 1, also known as 15 kDa oxygen-regulated protein, 17 kDa glucose-regulated protein, ORP-15, GRP-17, and HYOU1, is a member of the heat shock protein 7 family. Seven members from four different heat shock protein (HSP) families were identified including HYOU1 (ORP15), HSPC1 (HSP86), HSPA5 (Bip), HSPD1 (HSP6), and several isoforms of the two testis-specific HSP7 chaperones HSPA2 and HSPA1L. HYOU1 is highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. It is highly expressed in the liver and pancreas. HYOU1 is also expressed in macrophages within aortic atherosclerotic plaques and in breast cancers. HYOU1 has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. It may play a role as a molecular chaperone and participate in protein folding. Suppression of HYOU1 is associated with accelerated apoptosis. It is suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein is up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness.

        ORP150 の参考文献

        • Ikeda J., et al.,(1997), Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150. Biochem. Biophys. Res. Commun. 230:94-99.
        • Kaneda S., et al., (2000), Production of three distinct mRNAs of 150 kDa oxygen-regulated protein (ORP150) by alternative promoters: preferential induction of one species under stress conditions.J. Biochem. 128:529-538.
        • Takeuchi S., (2006), Molecular cloning, sequence, function and structural basis of human heart 150 kDa oxygen-regulated protein, an ER chaperone.Protein J. 25:517-528.

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