ORM2 Proteins, Antibodies, cDNA Clones Research Reagents

ORM2 (Orosomucoid 2, also known as AGP2; AGP-B; AGP-B'), located on 9q32, is a Protein Coding gene. The gene produces a 23603 Da protein composed of 201 amino acids. This gene encodes a key acute phase plasma protein. It belongs to the calycin superfamily, lipocalin family. ORM2 functions as a transport protein in the bloodstream. It seems that ORM2 function in modulating the activity of the immune system during the acute-phase reaction. The related pathways of ORM2 include Response to elevated platelet cytosolic Ca2+ and Innate Immune System.

ORM2 Protein (1)

    ORM2 Antibody (1)

      ORM2 cDNA Clone (25)

      BC015964

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_011016.2

      ORM2 qPCR Primer (1)

      ORM2 Lysate (1)

        ORM2 の背景知識

        ORM2 belongs to the calycin superfamily, lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids. Lipocalins can be found in gram-negative bacteria, vertebrate cells, and invertebrate cells, and plants. They are associated with many biological processes. ORM2 functions as a transport protein in the bloodstream. It is expressed by the liver and secreted in plasma. It seems that ORM2 function in modulating the activity of the immune system during the acute-phase reaction. It binds various hydrophobic ligands in the interior of its beta-barrel domain. It also binds synthetic drugs and influences their distribution and availability.

        ORM2 の参考文献

        • Davila S, et al. (2010) New genetic associations detected in a host response study to hepatitis B vaccine. Genes Immun. 11(3):232-8.
        • Zhang X, et al. (2012) The potential role of ORM2 in the development of colorectal cancer. PLoS One. 7(2):e31868.

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