OPCML Proteins, cDNA Clones Research Reagents

OPCML (Opioid Binding Protein/cell Adhesion Molecule Like, also known as OPCM; OBCAM; IGLON1), located on 11q25, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog. The gene produces a 38008 Da protein composed of 345 amino acids. This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. Diseases such as Ovarian Cancer and Hypogonadotropic Hypogonadism 14 With Or Without Anosmia are associated with OPCML. The related pathways of OPCML include the Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

OPCML Protein (3)

    OPCML cDNA Clone (39)

    NM_002545.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_177906.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_053848.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    OPCML Lysate (3)

      OPCML の背景知識

      Opioid-binding Cell Adhesion Molecule (OBCAM), also known as OPCML, is a GPI-anchored cell adhesion molecule in the plasma membrane. This neuron-specific protein consists of three immunoglobulin (Ig)-like domains anchored to the membrane through a glycosylphosphatidylinositol (GPI)-tail. OPCML also belongs to the member of the IgLON family, a subgroup of the immunoglobulin superfamily, consisting of three members, LAMP, OBCAM, and Neurotrimin. These molecules interact homophilically and heterophilically within the family, and OBCAM acts only as heterodimers with LAMP or Neurotrimin and possibly inhibits neurite outgrowth from cerebellar granule cells. The OBCAM has been presumed to play a role as a cell adhesion/recognition molecule. Furthermore, the OPCML protein defects may play an important role in the carcinogenesis of cervical or ovarian cancers, and this gene is regarded as a candidate TSG (tumor suppressor gene).

      OPCML の参考文献

      • Hachisuka A, et al. (2000) Developmental expression of opioid-binding cell adhesion molecule (OBCAM) in rat brain. Brain Res Dev Brain Res. 122(2): 183-91.
      • Miyata S, et al. (2003) Polarized targeting of IgLON cell adhesion molecule OBCAM to dendrites in cultured neurons. Brain Res. 979(1-2): 129-36.
      • Yamada M, et al. (2007) Synaptic adhesion molecule OBCAM; synaptogenesis and dynamic internalization. Brain Res. 1165: 5-14.
      • Sugimoto C, et al. (2010) OBCAM, an immunoglobulin superfamily cell adhesion molecule, regulates morphology and proliferation of cerebral astrocytes. J Neurochem. 112(3): 818-28.

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